My current research project is focused on elucidating the function of a novel gene called Mosaic that causes immune dysregulation. Dr. Dylan Chan, MD, is a pediatric otolaryngologist practicing at UCSF Benioff Children's Hospital in San Francisco, Calif. UCSF – SFGH – Div. The new UCSF lab, launched last month with the support of CZ Biohub and the Chan Zuckerberg Initiative (CZI), tested its first samples from COVID-19 patients on March 20, and is now capable of processing more than 2,600 samples per day, returning results in as little as 24 hours. John K. Chan, MD, is the Director of Gynecologic Oncology and a specialist in the surgical and medical treatment of ovarian and other complex pelvic cancers at the UCSF Helen Diller Family Comprehensive Cancer Center. A unique and defining trait of human behavior is our ability to communicate through speech. Vazquez SE, Ferré EM, Scheel DW, Sunshine S, Miao B, Mandel-Brehm C, Quandt Z, Chan AY, Cheng M, German M, Lionakis M, DeRisi JL, Anderson MS, de Jesus AA, Hou Y, Brooks S, Malle L, Biancotto A, Huang Y, Calvo KR, Marrero B, Moir S, Oler AJ, Deng Z, Montealegre Sanchez GA, Ahmed A, Allenspach E, Arabshahi B, Behrens E, Benseler S, Bezrodnik L, Bout-Tabaku S, Brescia AC, Brown D, Burnham JM, Caldirola MS, Carrasco R, Chan AY, Cimaz R, Dancey P, Dare J, DeGuzman M, Dimitriades V, Ferguson I, Ferguson P, Finn L, Gattorno M, Grom AA, Hanson EP, Hashkes PJ, Hedrich CM, Herzog R, Horneff G, Jerath R, Kessler E, Kim H, Kingsbury DJ, Laxer RM, Lee PY, Lee-Kirsch MA, Lewandowski L, Li S, Lilleby V, Mammadova V, Moorthy LN, Nasrullayeva G, O'Neil KM, Onel K, Ozen S, Pan N, Pillet P, Piotto DG, Punaro MG, Reiff A, Reinhardt A, Rider LG, Rivas-Chacon R, Ronis T, Rösen-Wolff A, Roth J, Ruth NM, Rygg M, Schmeling H, Schulert G, Scott C, Seminario G, Shulman A, Sivaraman V, Son MB, Stepanovskyy Y, Stringer E, Taber S, Terreri MT, Tifft C, Torgerson T, Tosi L, Van Royen-Kerkhof A, Wampler Muskardin T, Canna SW, Goldbach-Mansky R, Chan AY, Leiding JW, Liu X, Logan BR, Burroughs LM, Allenspach EJ, Skoda-Smith S, Uzel G, Notarangelo LD, Slatter M, Gennery AR, Smith AR, Pai SY, Jordan MB, Marsh RA, Cowan MJ, Dvorak CC, Craddock JA, Prockop SE, Chandrakasan S, Kapoor N, Buckley RH, Parikh S, Chellapandian D, Oshrine BR, Bednarski JJ, Cooper MA, Shenoy S, Davila Saldana BJ, Forbes LR, Martinez C, Haddad E, Shyr DC, Chen K, Sullivan KE, Heimall J, Wright N, Bhatia M, Cuvelier GDE, Goldman FD, Meyts I, Miller HK, Seidel MG, Vander Lugt MT, Bacchetta R, Weinacht KG, Andolina JR, Caywood E, Chong H, de la Morena MT, Aquino VM, Shereck E, Walter JE, Dorsey MJ, Seroogy CM, Griffith LM, Kohn DB, Puck JM, Pulsipher MA, Torgerson TR, Chinn IK, Chan A, Chen K, Chou J, Dorsey MJ, Hajjar J, Jongco AM, Keller MD, Kobrynski LJ, Kumanovics A, Lawrence MG, Leiding JW, Lugar PL, Orange JS, Patel K, Platt CD, Puck JM, Raje N, Romberg ND, Slack MA, Sullivan KE, Tarrant TK, Torgerson TR, Walter JE, Eriksson D, Bacchetta R, Gunnarsson HI, Chan A, Barzaghi F, Ehl S, Hallgren Å, van Gool F, Sardh F, Lundqvist C, Laakso SM, Rönnblom A, Ekwall O, Mäkitie O, Bensing S, Husebye ES, Anderson M, Kämpe O, Landegren N, Simeonov DR, Brandt AJ, Chan AY, Cortez JT, Li Z, Woo JM, Lee Y, Carvalho CMB, Indart AC, Roth TL, Zou J, May AP, Lupski JR, Anderson MS, Buaas FW, Rokhsar DS, Marson A, Simeonov DR, Gowen BG, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, Woo JM, Mitros T, Ray GJ, Curie GL, Naddaf N, Chu JS, Ma H, Boyer E, Van Gool F, Huang H, Liu R, Tobin VR, Schumann K, Daly MJ, Farh KK, Ansel KM, Ye CJ, Greenleaf WJ, Anderson MS, Bluestone JA, Chang HY, Corn JE, Marson A, Tsui JL, Estrada OA, Deng Z, Wang KM, Law CS, Elicker BM, Jones KD, Dell SD, Gudmundsson G, Hansdottir S, Helfgott SM, Volpi S, Gattorno M, Waterfield MR, Chan AY, Chung SA, Ley B, Shum AK, Li D, Streeten EA, Chan A, Lwin W, Tian L, Pellegrino da Silva R, Kim CE, Anderson MS, Hakonarson H, Levine MA, Stray-Pedersen A, Sorte HS, Samarakoon P, Gambin T, Chinn IK, Coban Akdemir ZH, Erichsen HC, Forbes LR, Gu S, Yuan B, Jhangiani SN, Muzny DM, Rødningen OK, Sheng Y, Nicholas SK, Noroski LM, Seeborg FO, Davis CM, Canter DL, Mace EM, Vece TJ, Allen CE, Abhyankar HA, Boone PM, Beck CR, Wiszniewski W, Fevang B, Aukrust P, Tjønnfjord GE, Gedde-Dahl T, Hjorth-Hansen H, Dybedal I, Nordøy I, Jørgensen SF, Abrahamsen TG, Øverland T, Bechensteen AG, Skogen V, Osnes LTN, Kulseth MA, Prescott TE, Rustad CF, Heimdal KR, Belmont JW, Rider NL, Chinen J, Cao TN, Smith EA, Caldirola MS, Bezrodnik L, Lugo Reyes SO, Espinosa Rosales FJ, Guerrero-Cursaru ND, Pedroza LA, Poli CM, Franco JL, Trujillo Vargas CM, Aldave Becerra JC, Wright N, Issekutz TB, Issekutz AC, Abbott J, Caldwell JW, Bayer DK, Chan AY, Aiuti A, Cancrini C, Holmberg E, West C, Burstedt M, Karaca E, Yesil G, Artac H, Bayram Y, Atik MM, Eldomery MK, Ehlayel MS, Jolles S, Flatø B, Bertuch AA, Hanson IC, Zhang VW, Wong LJ, Hu J, Walkiewicz M, Yang Y, Eng CM, Boerwinkle E, Gibbs RA, Shearer WT, Lyle R, Orange JS, Lupski JR, Chan AY, Punwani D, Kadlecek TA, Cowan MJ, Olson JL, Mathes EF, Sunderam U, Fu SM, Srinivasan R, Kuriyan J, Brenner SE, Weiss A, Puck JM, Punwani D, Wang H, Chan AY, Cowan MJ, Mallott J, Sunderam U, Mollenauer M, Srinivasan R, Brenner SE, Mulder A, Claas FH, Weiss A, Puck JM, Jennings P, Chan A, Schwartzberg P, Wakeland EK, Yuan D, Chan AY, Westcott JM, Mooney JM, Wakeland EK, Schatzle JD, Wandstrat AE, Nguyen C, Limaye N, Chan AY, Subramanian S, Tian XH, Yim YS, Pertsemlidis A, Garner HR, Morel L, Wakeland EK, ©2021 The Regents of the University of California, Current opinion in allergy and clinical immunology, The Journal of allergy and clinical immunology, The Journal of clinical endocrinology and metabolism, Annals of the New York Academy of Sciences, Journal of immunology (Baltimore, Md. jeffrey.hussmann@ucsf.edu. Exome Sequencing Reveals Mutations in AIRE as a Cause of Isolated Hypoparathyroidism. Learn more about Dr. Chan's specialties, training and contact information. Vazquez SE, Ferré EM, Scheel DW, Sunshine S, Miao B, Mandel-Brehm C, Quandt Z, Chan AY, Cheng M, German M, Lionakis M, DeRisi JL, Anderson MS Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases. We are looking for enthusiastic scientists to join our lab (undergraduate, graduate student, and postdoc). A postdoctoral fellow in the DeRisi lab, Caleigh Mandel-Brehm, led the study together with a clinical fellow at the Mayo Clinic, Divyanshu Dubey. Identification of novel, clinically correlated autoantigens in the monogenic autoimmune syndrome APS1 by proteome-wide PhIP-Seq. The role of SAP and the SLAM family in autoimmunity. Education; Bachelor of Science (Accounting), As a postdoctoral fellow with Jonathan Weissman at UCSF, he developed high-throughput CRISPR methods to … A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70. Non-UCSF providers and patients can send comments and/or concerns directly to the Senior Medical Director of the Clinical Labs or anonymously by calling the lab at 415-353-1667 or via our online form. The autoimmune targets in IPEX are dominated by gut epithelial proteins. Chan and Bove are collaborating on … Laboratory Phone: 415-206-3914. In 1999, he joined the laboratory of Professor Thomas Walz at Harvard Medical School. This campus directory is the property of the University of California San Francisco. Welcome to the UCSF Clinical Labs online laboratory manual. Immediately after the executive order was issued, Joe DeRisi, co-president of the Chan Zuckerberg Biohub (CZ Biohub), and his team jumped into action by turning empty UCSF lab space adjacent to the CZ Biohub into a CLIA-certified COVID-19 testing facility. We are proud to offer an extensive menu of clinical tests and services through our four CLIA-certified, CAP-accredited laboratories at Moffitt-Long Hospital, Mission Bay Hospitals, Mt. DeRisi was texting daily with Priscilla Chan, MD ’12, mulling the right problem to tackle. UCSF – SFGH – Div. While much of this processing has been localized to the peri-sylvian cortex, including Broca’s and Wernicke’s areas, the fundamental organizational principles of the neural circuits within these areas are completely unknown. Jonah Chan Dr. Chan (full profile here) is the Debbie and Andy Rachleff Distinguished Professor of Neurology at UCSF, directs The Chan Lab, and is a member of the Program in Neurosciences, the Biomedical Sciences Program and the MS Research Group at UCSF. A postdoctoral fellow in the DeRisi lab, Caleigh Mandel-Brehm, led the study together with a clinical fellow at the Mayo Clinic, Divyanshu Dubey. I'm a pediatric immunologist and rheumatologist dedicated to improving our understanding of immune regulation to advance care for patients with immune system disorders. Zion, and China Basin. Update from the Dean – November 2018: 5. Update from the Dean – July 2018: 7. Dr. Chan (full profile here) is the Debbie and Andy Rachleff Distinguished Professor of Neurology at UCSF, directs The Chan Lab, and is a member of the Program in Neurosciences, the Biomedical Sciences Program and the MS Research Group at UCSF. This partnership would be crucial in ramping up testing across the state. Treatment of juvenile idiopathic arthritis. B cell-intrinsic CD84 and Ly108 maintain germinal center B cell tolerance. Laboratory Location: Division of Experimental Medicine San Francisco General Hospital University of California San Francisco. He focused on understanding how vocal tract movements are represented in the sensorimotor cortex and harnessed these findings to design a decoder that could synthesize speech from brain activity. Please contact Dr. Chang by email to express interest. New York Stem Cell Foundation- Robertson Fellowship, Neural Auditory Response Demo (requires Chrome). S upported by an executive order from California Governor Gavin Newsom, the Chan Zuckerberg Initiative (CZI), the Chan Zuckerberg Biohub (CZ Biohub), and UC San Francisco (UCSF) are helping frontline healthcare facilities and local authorities better fight the COVID-19 pandemic, using their capabilities to increase the volume of local clinical testing. Author Correction: Discovery of stimulation-responsive immune enhancers with CRISPR activation. For UCSF graduate, DACA gives a chance to fight cancer: 2. Central tolerance to self revealed by the autoimmune regulator. Early vs. delayed diagnosis of severe combined immunodeficiency: a family perspective survey. Email: jonathan.woo [at] ucsf.edu After obtaining a bachelor's degree in Molecular and Cell Biology and master's in Biomedical Laboratory Science I spent many years at the Genomics Core Facility. He also conducted his doctoral studies in the Chang lab within the joint UCSF/UC Berkeley Bioengineering PhD Program. Stopping cancer in its tracks: 6. Primary immunodeficiency diseases: Genomic approaches delineate heterogeneous Mendelian disorders. A student in Rod MacKinnon’s lab, he used X-ray crystallography and electrophysiology to study how ion channels are regulated by calcium, voltage, and pH. In 2014, Dr. Chan established the UCSF Children’s Communication Center, which is devoted to delivering multidisciplinary care for families of deaf and hard of hearing children, performing community outreach and education, and conducting clinical and translational research projects. These methods allow us to examine both local circuitry and global network dynamics spanning multiple cortical and sub-cortical regions with unparalleled spatial and temporal resolution in humans. Combination drug therapy overcomes drug-resistant lung cancer in the lab: 4. Scientists at Chan Zuckerberg (CZ) Biohub, Mayo Clinic and University of California, San Francisco (UCSF), have discovered an autoimmune disease that appears to affect men with testicular cancer. His laboratory studies three-dimensional structures of macromolecule by single particle cryo-EM. The laboratory is in the Department of Neurology and part of the Weill Institute for Neurosciences at the University of California, San Francisco. Vazquez SE, Ferré EM, Scheel DW, Sunshine S, Miao B, Mandel-Brehm C, Quandt Z, Chan AY, Cheng M, German M, Lionakis M, DeRisi JL, Anderson MS Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases. He joined Dr. Samuel Pleasure's lab at UCSF in 2007 as a lab manager and has since expanded to managing Dr. Stephen Fancy's lab in 2013 and Dr. Jonah Chan's lab in 2017. of Exp. The Chan Laboratory is in the Division of Neuroimmunology and Glial Biology and a member of the Innovation Program for Remyelination and Repair. Cynthia … Vicky Chan Financial Analyst, Yamamoto Lab and UCSF Program For Breakthrough Biomedical Research Vicky.Chan@ucsf.edu. The Chan laboratory has a long-standing interest in fundamental glial/neuronal interactions and the molecular mechanisms that regulate myelination. Laboratory Location: Division of Experimental Medicine San Francisco General Hospital University of California San Francisco. In 2014, Dr. Chan established the UCSF Children’s Communication Center, which is devoted to delivering multidisciplinary care for families of deaf and hard of hearing children, performing community outreach and education, and conducting clinical and translational research projects. Post-doc Joint with Carol Gross Lab. Lab Recruitment. Laboratory Phone: 415-206-3914. We are affiliated with the UCSF Tetrad, BMS, and DSCB graduate programs. Non-UCSF providers and patients can send comments and/or concerns directly to the Senior Medical Director of the Clinical Labs or anonymously by calling the lab at 415-353-1667 or via our online form. The Chan Lab Jonah Chan, PhD is principal investigator whose lab is working to understand the fundamental glial/neuronal interactions and the molecular mechanisms that regulate myelination. Our laboratory is interested in determining the basic mechanisms that underlie our ability to perceive and produce speech. Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus. Chan earned her medical degree and doctoral degree in biochemistry at the Keck School of Medicine of the University of Southern California. The mission of the Quality and Informatics Lab (QUIL) at UCSF is to improve patient outcomes; we use EHR data to develop and test measures of quality and medication safety. Ph.D., Biological Sciences (Cell Biology, Biophysics), Blobel Lab, The Rockefeller University (2009) Postdoctoral Fellow, Weissman Lab, UCSF (2010-2015) Publications. Please visit our lab website by clicking here. Drs. UCSF laboratory scientists begin working on a test in-house By late February, the Bay Area had begun bracing for its own surge of COVID cases. A large CRISPR-induced bystander mutation causes immune dysregulation. Antigen-specific responses and ANA production in B6.Sle1b mice: a role for SAP. Chan earned her medical degree and doctoral degree in biochemistry at the Keck School of Medicine of the University of Southern California. Diagnostic Interpretation of Genetic Studies in Patients with Primary Immunodeficiency Diseases: A Working Group Report of the Primary Immunodeficiency Diseases Committee of the American Academy of Allergy, Asthma, and Immunology. Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases. Selected All Honors and Awards. He has been an HHMI Investigator since 2015. He joined Dr. Samuel Pleasure's lab at UCSF in 2007 as a lab manager and has since expanded to managing Dr. Stephen Fancy's lab in 2013 and Dr. Jonah Chan's lab in 2017. CLNCL LAB MICROBIOLOGY ... Crystal.Chan@ucsf.edu Telephone (415) 353-1268. Analysis of pulmonary features and treatment approaches in the COPA syndrome. Hematopoietic Cell Transplantation in Patients With Primary Immune Regulatory Disorders (PIRD): A Primary Immune Deficiency Treatment Consortium (PIDTC) Survey. The epic journey to better medicines: 8. Chan Zuckerberg Biohub and UCSF boost Bay Area coronavirus testing. Primary immune regulatory disorders: a growing universe of immune dysregulation. Combined immunodeficiency due to MALT1 mutations, treated by hematopoietic cell transplantation. The Department of Surgery at the University of California, San Francisco is one of the leading surgical departments in the world. Chan is a member of the UCSF prostate cancer center. She completed her residency in ophthalmology at the University of Rochester Flaum Eye Institute, and a fellowship in cornea and external disease at UCSF. It has a rich history of scientific, educational, and clinical advancements. To address this, our laboratory applies a variety of experimental approaches including psychophysics, local field potential and microelectrode array recordings, electrocortical stimulation, and real-time signal processing. In 2006, he became a faculty at UCSF and stayed there ever since. She completed her residency in ophthalmology at the University of Rochester Flaum Eye Institute, and a fellowship in cornea and external disease at UCSF. University of California - San Francisco. Update from the Dean – May 2019: 3. He also conducted his doctoral studies in the Chang lab within the joint UCSF/UC Berkeley Bioengineering PhD Program. UCSF to Expand COVID-19 Clinical Laboratory Facilities With the Collaboration of the Chan Zuckerberg Biohub. Please visit our lab website by clicking here. Our ongoing research is not only deepening understanding of speech and its disorders, but also is leading directly to safer mapping methods to preserve language function during brain surgery. UCSF Profiles is managed by the UCSF Clinical and Translational Science Institute (CTSI), part of the Clinical and Translational Science Award program funded by the National Center for Advancing Translational Sciences (Grant Number UL1 TR000004) at the National Institutes of Health (NIH). Scientists at Chan Zuckerberg (CZ) Biohub, Mayo Clinic and University of California, San Francisco (UCSF), have discovered an autoimmune disease that appears to affect men with testicular cancer. Chan received a CapCURE (now known as Prostate Cancer Foundation) Young Investigator Award; and was awarded the Steven & Christine Burd-Safeway Distinguished Professorship in 2009. My clinical practice is focused on diagnosing and managing patients with complex or unknown immune system disorders, and my research area is focused on studying genes that regulate the immune system. : 1950). Over the course of time in the Pleasure lab he has worked with graduate students and post-docs on various projects focusing on forebrain development. To request changes to a department listing please open a ticket at help.ucsf.edu, or contact the IT Service Desk at (415) 514-4100. Matt Jones Drs. Principal investigator Lab members Staff Former lab members Photo Who Research interests Rada Savic, PhD Principal Investigator rada.savic@ucsf.edu I work on methodological advancement and application of systems pharmacology models to drug development and therapy optimization problems in tuberculosis (TB), HIV, oncology, and diabetes. ... an associate professor in the UCSF Institute for Neurodegenerative Diseases and Chan Zuckerberg Biohub Investigator. Over the course of time in the Pleasure lab he has worked with graduate students and post-docs on various projects focusing on forebrain development. Dr. Chan oversees the Division’s activities and … UCSF staff should utilize the incident reporting system to communicate problems and/or concerns. The Chan Lab Jonah Chan, PhD is principal investigator whose lab is working to understand the fundamental glial/neuronal interactions and the molecular mechanisms that regulate myelination. A new lab can process up to 2,000 samples daily and return results in as fast as 24 hours. From technical troubleshooting to data analysis to overall project management I worked on … of Exp. In 2014, Dr. Chan established the UCSF Children’s Communication Center, which is devoted to delivering multidisciplinary care for families of deaf and hard of hearing children, performing community outreach and education, and conducting clinical and translational research projects. Medicine Main Office: Office Phone: 415-206-8177 Fax: 415-206-8091 Excellence in Graduate Student Mentoring Award, UCSF BMS program (2019) Chan Zuckerberg Initiative Ben Barres Early Career Acceleration Award (2018) Our central goal is to provide a mechanistic account for the major properties of speech behavior in normal speakers and those with language disorders. Medicine Main Office: Office Phone: 415-206-8177 Fax: 415-206-8091 Discovery of stimulation-responsive immune enhancers with CRISPR activation. The Chan lab would provide opportunities for Scholars interested in the role of extracellular matrix in ocular disease, epigenetics, and translational vision science. He is a member of the Neuroscience Graduate Program, the Division of Neuroimmunology and Glial Biology and Co-Director of the Innovation Program for Remyelination and Repair at UCSF. 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